6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

Base Information

Chemical Name:6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide
CAS No.:144457-14-7
Molecular Formula:C₂₁H₁₉F₃N₄O₃
Molecular Weight:432.402
Hs Code.:

Synonyms:6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

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Chemical Property of 6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

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Technology Process of 6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

There total 9 articles about 6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 455-14-1
4-trifluoromethylphenylamine

: 144457-23-8
4-ethoxycarbonyl-5-p. acetylaminophenyl-6-methyl-4,5-dihydropyridazin-3(2H)-one

: 144457-14-7
6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

Guidance literature:: With dmap; In diethylene glycol; at 120 ℃; for 6h;

Reference yield: 50.0%

: 108-24-7
acetic anhydride

: 144457-13-6
6-methyl-5-p. aminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

: 144457-14-7
6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

Guidance literature:: at 100 ℃; for 0.25h;

Reference yield:

: 117903-12-5
ethyl-2-ethoxycarbonyl-3-p.nitrophenyl-4-oxopentanoate

: 144457-14-7
6-methyl-5-p. acetylaminophenyl-4,5-dihydropyridazin-3(2H)-on-4-p. trifluoromethylphenylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / 10percent Pd/C / 2585.7 Torr / Ambient temperature

2: 80.4 percent / 1 h / Heating

3: 83 percent / hydrazine hydrate / acetic acid; H₂O / 4.5 h / Heating

4: 69 percent / 4-dimethylaminopyridine / bis-(2-hydroxy-ethyl) ether / 6 h / 120 °C

With dmap; hydrogen; hydrazine hydrate; palladium on activated charcoal; In water; acetic acid; diethylene glycol;