C₅₀H₅₁N₆O₁₃PS

Base Information

• Chemical Name: C₅₀H₅₁N₆O₁₃PS
• CAS No.: 224186-63-4
• Molecular Formula: C₅₀H₅₁N₆O₁₃PS
• Molecular Weight: 1007.03
• Mol file: 224186-63-4.mol

Synonyms:C₅₀H₅₁N₆O₁₃PS

Chemical Property of C₅₀H₅₁N₆O₁₃PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₅₁N₆O₁₃PS

There total 7 articles about C₅₀H₅₁N₆O₁₃PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C55H57N6O15PS → C50H51N6O13PS (224186-63-4)

Guidance literature:

With hydrazine hydrate; In pyridine; acetic acid; at 0 ℃;

DOI:10.1080/15257779908043091

Reference yield:

C55H57N6O15P (224186-73-6) → C50H51N6O13PS (224186-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: elementary sulfur / pyridine / 0.5 h / 50 °C

2: hydrazine hydrate / acetic acid / 0.17 h / 0 °C

With sulfur; hydrazine hydrate; In pyridine; acetic acid; 1: sulfurization / 2: Substitution;

DOI:10.1080/15257770008033035

Reference yield:

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-cytidine (91592-66-4) → C50H51N6O13PS (224186-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-tetrazole / acetonitrile / 1 h / 20 °C

1.2: diethyldithiocarbonate disulfide / acetonitrile / 0.75 h / 20 °C

2.1: hydrazine hydrate / pyridine; acetic acid / 0.5 h / 20 °C

With 1H-tetrazole; hydrazine hydrate; In pyridine; acetic acid; acetonitrile; 1.1: Substitution / 1.2: Oxidation / 2.1: Hydrolysis;

DOI:10.1080/07328319908044844

upstream raw materials:

5'-O-(4-4'-dimethoxytrityl)thymidine

C₅₅H₅₇N₆O₁₅P

5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]

N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-cytidine

Refernces

• 1、 Eleuteri, Alessandra,Capaldi, Daniel C.,Cole, Douglas L.,Ravikumar, Vasulinga T.. "Oligodeoxyribonucleotide phosphorothioates: Substantial reduction of (N- 1)-mer content through the use of trimeric phosphoramidite synthons". . p. 475 - 483. Retrieved 2007/10/03.