2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

Base Information

Chemical Name:2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid
CAS No.:1187990-83-5
Molecular Formula:C₂₀H₁₈N₄O₄
Molecular Weight:378.387
Hs Code.:

Synonyms:2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

Suppliers and Price of 2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

There total 2 articles about 2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.6%

: 201230-82-2
carbon monoxide

: 1187990-82-4
2-(4-bromopyridin-2-yl)-4-hydroxy-N-(1-methyl-1-phenylethyl)pyrimidine-5-carboxamide

: 1187990-83-5
2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; palladium diacetate; In dimethyl sulfoxide; at 120 ℃; for 0.5h;
DOI:10.1021/acs.jmedchem.6b01242

Reference yield:

: 585-32-0
2-phenyl-2-propylamine

: 1187990-83-5
2-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)isonicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole; triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 70 °C / Inert atmosphere

1.2: 0.5 h / 70 °C / Inert atmosphere

2.1: palladium diacetate; potassium acetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 0.5 h / 120 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; palladium diacetate; triethylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.6b01242