1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid

Base Information

• Chemical Name: 1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid
• CAS No.: 99273-68-4
• Molecular Formula: C₁₉H₂₁ClO₄S
• Molecular Weight: 380.892
• Mol file: 99273-68-4.mol

Synonyms:1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid

Chemical Property of 1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid

There total 2 articles about 1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

β-p-Chlorbenzoyl-β'-p-methylbenzoyl-diethylsulfon → 1-p-Chlorphenyl-7-p-tolyl-4-thia-heptan-1,7-diol-4,4-dioxid + 1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid (99273-68-4)

Guidance literature:

With DMAB; In 1,4-dioxane; acetic acid; at 70 ℃; for 24h;

DOI:10.1002/ardp.19853180907

Reference yield:

Bis-<β-(p-chlorbenzoyl)-ethyl>-sulfon (63261-19-8) → 1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid (99273-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaCN / 1.) EtOH, reflux, 8 h, 2.) H₂O, room temp.

2: 42 percent / DMAB / dioxane; acetic acid / 24 h / 70 °C

With sodium cyanide; In 1,4-dioxane; acetic acid;

DOI:10.1002/ardp.19853180907

Reference yield:

1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid (99273-68-4) → 4-oxo-4-(4-methylphenyl)butanenitrile (55234-57-6) + 5-p-Chlorphenyl-1,2-oxathiolan-2-oxid

Guidance literature:

With hydrogenchloride; sodium cyanide; Yield given. Multistep reaction. Yields of byproduct given; 1.) aq. EtOH, reflux, 2.) 2 d;

DOI:10.1002/ardp.19853180908

upstream raw materials:

Bis-<β-(p-chlorbenzoyl)-ethyl>-sulfon

Downstream raw materials:

4-oxo-4-(4-methylphenyl)butanenitrile