4-Oxo-4-tolylbutanenitrile

Base Information

• Chemical Name: 4-Oxo-4-tolylbutanenitrile
• CAS No.: 55234-57-6
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2926909090
• Mol file: 55234-57-6.mol

Synonyms:4-Oxo-4-tolylbutanenitrile

Chemical Property of 4-Oxo-4-tolylbutanenitrile

Chemical Property:

• PSA: 40.86000
• LogP: 2.48148

Purity/Quality:

97% ^*data from raw suppliers

4-Oxo-4-p-tolylbutanenitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Oxo-4-tolylbutanenitrile

There total 28 articles about 4-Oxo-4-tolylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

S-2-pyridyl 4-methylbenzothiolate (74032-45-4) + acrylonitrile (107-13-1,25014-41-9) → 4-oxo-4-(4-methylphenyl)butanenitrile (55234-57-6)

Guidance literature:

With C₅₃H₇₄CoN₅O₁₅⁽¹⁺⁾*ClO₄^(1-)*H₂O; ammonium chloride; zinc; In acetonitrile; at 19 - 25 ℃; for 16h; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1002/adsc.201700913

Reference yield: 87.0%

4-methyl-benzaldehyde (104-87-0) + acrylonitrile (107-13-1,25014-41-9) → 4-oxo-4-(4-methylphenyl)butanenitrile (55234-57-6)

Guidance literature:

With Cu doped graphitic carbon nitride; In water; at 20 ℃; for 7h; Sealed tube; Irradiation; Green chemistry;

DOI:10.1002/ejoc.202000945

Reference yield: 83.0%

butanedinitrile (110-61-2) + 4-methylphenylboronic acid (5720-05-8) → 4-oxo-4-(4-methylphenyl)butanenitrile (55234-57-6)

Guidance literature:

With [2,2]bipyridinyl; palladium(II) acetylacetonate; toluene-4-sulfonic acid; In water; toluene; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.joc.9b02999

upstream raw materials:

sodium cyanide

1,7-Di-p-tolyl-1-oxo-4-thia-heptan-7-ol-4,4-dioxid

1-p-Chlorphenyl-7-p-tolyl-7-oxo-4-thia-heptan-1-ol-4,4-dioxid

4-Methanesulfinyl-4-phenylsulfanyl-4-p-tolyl-butyronitrile

Downstream raw materials:

5-(p-tolyl)-3,4-dihydro-2H-pyrrole

2-(4-methylphenyl)pyrrolidine

(R)-4-hydroxy-4-p-tolylbutanenitrile

(R)-γ-(4-methylphenyl)-γ-butyrolactone