benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate

Base Information

• Chemical Name: benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate
• CAS No.: 127944-62-1
• Molecular Formula: C₂₂H₂₇NO₄
• Molecular Weight: 369.461
• Mol file: 127944-62-1.mol

Synonyms:benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate

Chemical Property of benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate

There total 1 articles about benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methyl-N-(2-methoxyethyl)amine (38256-93-8) + (3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid (116129-80-7) → benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate (127944-62-1)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1.) CH₂Cl₂, -10 deg C, 3 min, 2a.) -10 deg, 15 min, 2b.) RT, 2 h;

DOI:10.1021/jm00169a024

Reference yield: 94.0%

benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate (127944-62-1) → (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionic acid (127944-66-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h;

DOI:10.1021/jm00169a024

Reference yield:

benzyl (2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionate (127944-62-1) → (R)-2-Benzyl-N1-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N4-(2-methoxy-ethyl)-N4-methyl-succinamide (127944-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / H₂ / 10percent Pd/C / methanol / 1 h

2: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, 16 h

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00169a024

upstream raw materials:

N-methyl-N-(2-methoxyethyl)amine

(3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid

Downstream raw materials:

(2R)-2-benzyl-3-<<(2-methoxyethyl)methylamino>carbonyl>propionic acid

(R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-methoxy-ethyl)-N⁴-methyl-succinamide