2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid

Base Information

• Chemical Name: 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid
• CAS No.: 920509-51-9
• Molecular Formula: C₁₈H₁₅Cl₂N₅O₅
• Molecular Weight: 452.254

Synonyms:2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid

Chemical Property of 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid

Chemical Property:

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Technology Process of 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid

There total 7 articles about 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile → 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid (920509-51-9)

Guidance literature:

With hydrogenchloride; acetic acid; at 120 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm4019299

Reference yield:

3,4,5-trichloronitrobenzen (20098-48-0) → 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid (920509-51-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

2.1: tin(ll) chloride; hydrogenchloride / ethanol / 110 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 60 °C / Inert atmosphere

4.1: acetic acid; hydrogenchloride / water / 24 h / 120 °C

5.1: sodium nitrate; hydrogenchloride / water / 0.5 h / 0 °C / Inert atmosphere

5.2: 0 °C / Inert atmosphere

6.1: acetic acid; sodium acetate / 1.5 h / 20 - 120 °C / Inert atmosphere

7.1: acetic acid; hydrogenchloride / 48 h / 120 °C / Inert atmosphere

With hydrogenchloride; sodium nitrate; potassium tert-butylate; sodium acetate; potassium carbonate; acetic acid; tin(ll) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm4019299

Reference yield:

2-(2,6-dichloro-4-nitrophenyl)acetonitrile (88135-30-2) → 2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)methyl]phenyl]-3,5-dioxo-4H-1,2,4-triazine-6-carboxylic acid (920509-51-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tin(ll) chloride; hydrogenchloride / ethanol / 110 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 60 °C / Inert atmosphere

3.1: acetic acid; hydrogenchloride / water / 24 h / 120 °C

4.1: sodium nitrate; hydrogenchloride / water / 0.5 h / 0 °C / Inert atmosphere

4.2: 0 °C / Inert atmosphere

5.1: acetic acid; sodium acetate / 1.5 h / 20 - 120 °C / Inert atmosphere

6.1: acetic acid; hydrogenchloride / 48 h / 120 °C / Inert atmosphere

With hydrogenchloride; sodium nitrate; potassium tert-butylate; sodium acetate; acetic acid; tin(ll) chloride; In tetrahydrofuran; ethanol; water;

DOI:10.1021/jm4019299

upstream raw materials:

ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazineylidene)acetyl)carbamate

2-(4-amino-2,6-dichlorophenyl)acetonitrile

3,4,5-trichloronitrobenzen

2-(2,6-dichloro-4-nitrophenyl)acetonitrile

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