2,6-Dichloro-4-nitrobenzeneacetonitrile

Base Information

• Chemical Name: 2,6-Dichloro-4-nitrobenzeneacetonitrile
• CAS No.: 88135-30-2
• Molecular Formula: C8H4Cl2N2O2
• Molecular Weight: 231.038
• Mol file: 88135-30-2.mol

Synonyms:2,6-dichloro-4-nitrobenzylnitrile;Benzenemethanol,2,6-dichloro-4-methoxy;(2,6-dichloro-4-methoxy-phenyl)-methanol;2,6-Dichlor-4-methoxybenzylalkohol;2,5-DIBROMO-4-CHLORO-4,4,5-TIFLUOROPENTAN-1-OL;2,6-dichloro-4-methoxybenzyl alcohol;(2,6-dichloro-4-nitro-phenyl)-acetonitrile;

Chemical Property of 2,6-Dichloro-4-nitrobenzeneacetonitrile

Chemical Property:

• PSA: 69.61000
• LogP: 3.49088

Purity/Quality:

99% ^*data from raw suppliers

2,6-DICHLORO-4-NITROBENZENEACETONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dichloro-4-nitrobenzeneacetonitrile

There total 6 articles about 2,6-Dichloro-4-nitrobenzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4,5-trichloronitrobenzen (20098-48-0) + ethyl 2-cyanoacetate (105-56-6) → 2-(2,6-dichloro-4-nitrophenyl)acetonitrile (88135-30-2)

Guidance literature:

ethyl 2-cyanoacetate; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

3,4,5-trichloronitrobenzen; In dimethyl sulfoxide; for 16h;

Reference yield: 96.56%

ethyl 2-cyano-2-(2,6-dichloro-4-nitrophenyl)acetate → 2-(2,6-dichloro-4-nitrophenyl)acetonitrile (88135-30-2)

Guidance literature:

With water; lithium chloride; In dimethyl sulfoxide; at 165 ℃; for 1h;

Reference yield:

methylthioacetonitrile (35120-10-6) + 3,5-dichloro-1-nitrobenzene (618-62-2) → 2-(2,6-dichloro-4-nitrophenyl)acetonitrile (88135-30-2)

Guidance literature:

With sodium hydroxide; at 0 - 20 ℃; for 24h;

upstream raw materials:

2,6-dichloro-4-nitro-anisole

3,4,5-trichloronitrobenzen

ethyl 2-cyanoacetate

methylthioacetonitrile

Downstream raw materials:

(2,6-dichloro-4-nitro-phenyl)-acetic acid

6-(4-(bromomethyl)-2,6-dichlorobenzyl)-4-isopropylpyridazin-3(2H)-one

[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

6-(4-amino-2,6-dichlorobenzyl)-4-isopropyl-2-methyl-2H-pyridazin-3-one

Refernces

• 1、 -. "THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS". Paragraph 0385. . Retrieved 2020/03/09.
• 2、 -. "CYCLOPROPYL DERIVATIVES AS ROR-GAMMA MODULATORS". Page/Page column 27. . Retrieved 2018/03/02.