1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole

Base Information

• Chemical Name: 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole
• CAS No.: 132968-35-5
• Molecular Formula: C₁₄H₁₄N₄O₅
• Molecular Weight: 318.289
• Mol file: 132968-35-5.mol

Synonyms:1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole

Chemical Property of 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole

There total 3 articles about 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-carbonylimidazolyl 1-benzyl-5-nitroimidazole-4-carboxylate (133124-61-5) + methoxycarbonylmethylamine (616-34-2) → 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole (132968-35-5)

Guidance literature:

In tetrahydrofuran; dichloromethane; for 0.5h; Ambient temperature;

Reference yield:

benzyl chloride (100-44-7) → 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole (132968-35-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) sodium carbonate, 2) NaOH, KMnO₄ / 1) DMF, 2) water, 36 h

2: 1 h / Heating

3: 96 percent / tetrahydrofuran; CH₂Cl₂ / 0.5 h / Ambient temperature

With sodium hydroxide; potassium permanganate; sodium carbonate; In tetrahydrofuran; dichloromethane;

Reference yield:

5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid (69195-96-6) → 1-benzyl-4-(N-methoxycarbonylmethyl)carbamoyl-5-nitroimidazole (132968-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / Heating

2: 96 percent / tetrahydrofuran; CH₂Cl₂ / 0.5 h / Ambient temperature

In tetrahydrofuran; dichloromethane;

upstream raw materials:

N-carbonylimidazolyl 1-benzyl-5-nitroimidazole-4-carboxylate

methoxycarbonylmethylamine

benzyl chloride

5-nitro-1-(phenylmethyl)-1H-imidazole-4-carboxylic acid

Downstream raw materials:

3-benzyl-4,5,7,8-tetrahydro-6H-imidazo<4,5-e><1,4>diazepine-5,8-dione

5-amino-1-benzyl-4-(N-carboxymethyl)carbamoylimidazole

5-amino-1-benzyl-4-(N-methoxycarbonylmethyl)carbamoylimidazole