Technology Process of (2R,3S,4S)-1,2-O-cyclohexylidene-3,4-O-dibenzylhex-5-ene-1,2,3,4-tetrol
There total 3 articles about (2R,3S,4S)-1,2-O-cyclohexylidene-3,4-O-dibenzylhex-5-ene-1,2,3,4-tetrol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2R,3S,4S)-1,2-O-cyclohexylidenehex-5-ene-1,2,3,4-tetrol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 60 ℃;
for 1h;
Inert atmosphere;
benzyl bromide;
In
tetrahydrofuran; mineral oil;
at 20 - 60 ℃;
for 3h;
Inert atmosphere;
DOI:10.1016/j.tetasy.2012.05.011
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 60 °C / Inert atmosphere
3.2: 3 h / 20 - 60 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; mineral oil;
1.1: Grignard reaction;
DOI:10.1016/j.tetasy.2012.05.011
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 60 °C / Inert atmosphere
2.2: 3 h / 20 - 60 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; mineral oil;
DOI:10.1016/j.tetasy.2012.05.011
