2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine

Base Information

• Chemical Name: 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine
• CAS No.: 474099-99-5
• Molecular Formula: C₂₆H₃₅N₇O
• Molecular Weight: 461.61

Synonyms:2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine

Chemical Property of 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine

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Technology Process of 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine

There total 3 articles about 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-phenyl-6-trichloromethyl-[1,3,5]triazine (474099-95-1) → 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine (474099-99-5)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm020288y

Reference yield:

2-phenyl-4,6-bis-trichloromethyl-[1,3,5]triazine (24504-22-1) → 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine (474099-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / dimethylformamide / 20 - 60 °C

2: triethylamine; H₂ / Pd/C / ethanol

With hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020288y

Reference yield:

2-((R)-1-Butoxy-ethyl)-4-((2S,6R)-2,6-dimethyl-piperazin-1-yl)-pyrimidine → 2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-methyl-6-phenyl-[1,3,5]triazine (474099-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaHCO₃ / dimethylformamide / 20 - 60 °C

2: triethylamine; H₂ / Pd/C / ethanol

With hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020288y

upstream raw materials:

2-{(3S,5R)-4-[2-((R)-1-Butoxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-4-phenyl-6-trichloromethyl-[1,3,5]triazine

2-phenyl-4,6-bis-trichloromethyl-[1,3,5]triazine

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