methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

Base Information

Chemical Name:methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate
CAS No.:87011-68-5
Molecular Formula:C₁₈H₃₀BrNO₃
Molecular Weight:388.345
Hs Code.:

Synonyms:methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

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Chemical Property of methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

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Technology Process of methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

There total 7 articles about methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10463-42-0
3,4-dimethyl-cyclohex-2-enone

: 87011-68-5
methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg; 2.) copper(I) iodide / 1.) ether, RT_., 15 min; 2.) dimethyl sufide, ether, 0 deg C, then rt.; 3.) 0 deg C, 2 h, rt. 12 h

2: 1.) ozone; 2.) p-toluenesulfonic acid / 1.) CH₂Cl₂, MeOH, -78 deg C, 4 h; 2.) 1 h, rt.

3: 1.) acetyl chloride; MeLi / 1.) ether, rt.; 2.) THF, -78 deg C, 15 min, then 2 h

4: 0.65 N HCl

5: 4.51 g / 1.) NaH / various solvent(s) / 2 h / Ambient temperature

With hydrogenchloride; copper(l) iodide; methyllithium; sodium hydride; toluene-4-sulfonic acid; ozone; magnesium; acetyl chloride; In various solvent(s);
DOI:10.1021/ja00294a046

Reference yield:

: 87011-65-2
methyl (trans-3,4-dimethoxybutyl-3-(4-pentenyl)-1-cyclohexen-1-yl)-carbonate

: 87011-68-5
methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) acetyl chloride; MeLi / 1.) ether, rt.; 2.) THF, -78 deg C, 15 min, then 2 h

2: 0.65 N HCl

3: 4.51 g / 1.) NaH / various solvent(s) / 2 h / Ambient temperature

With hydrogenchloride; methyllithium; sodium hydride; acetyl chloride; In various solvent(s);
DOI:10.1021/ja00294a046

Reference yield:

: 87011-66-3
(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

: 87011-68-5
methyl 2-bromo-6-<(1α,6β)-2-<(dimethylamino)methyl>-1,6-dimethyl-3-oxo-cyclohexyl>-2-hexenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 0.65 N HCl

2: 4.51 g / 1.) NaH / various solvent(s) / 2 h / Ambient temperature

With hydrogenchloride; sodium hydride; In various solvent(s);
DOI:10.1021/ja00294a046