(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

Base Information

Chemical Name:(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone
CAS No.:87011-66-3
Molecular Formula:C₁₇H₃₃NO₃
Molecular Weight:299.454
Hs Code.:

Synonyms:(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

Chemical Property:

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Technology Process of (3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

There total 5 articles about (3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10463-42-0
3,4-dimethyl-cyclohex-2-enone

: 87011-66-3
(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg; 2.) copper(I) iodide / 1.) ether, RT_., 15 min; 2.) dimethyl sufide, ether, 0 deg C, then rt.; 3.) 0 deg C, 2 h, rt. 12 h

2: 1.) ozone; 2.) p-toluenesulfonic acid / 1.) CH₂Cl₂, MeOH, -78 deg C, 4 h; 2.) 1 h, rt.

3: 1.) acetyl chloride; MeLi / 1.) ether, rt.; 2.) THF, -78 deg C, 15 min, then 2 h

With copper(l) iodide; methyllithium; toluene-4-sulfonic acid; ozone; magnesium; acetyl chloride;
DOI:10.1021/ja00294a046

Reference yield:

: 82343-62-2
methyl (trans-3,4-dimethyl-3-(4-pentenyl)-1-cyclohexen1-yl)-carbonate

: 87011-66-3
(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) ozone; 2.) p-toluenesulfonic acid / 1.) CH₂Cl₂, MeOH, -78 deg C, 4 h; 2.) 1 h, rt.

2: 1.) acetyl chloride; MeLi / 1.) ether, rt.; 2.) THF, -78 deg C, 15 min, then 2 h

With methyllithium; toluene-4-sulfonic acid; ozone; acetyl chloride;
DOI:10.1021/ja00294a046

Reference yield:

: 51-80-9
bis-(dimethylamino)methane

: 87011-65-2
methyl (trans-3,4-dimethoxybutyl-3-(4-pentenyl)-1-cyclohexen-1-yl)-carbonate

: 87011-66-3
(3R,4S)-3-(4,4-Dimethoxy-butyl)-2-dimethylaminomethyl-3,4-dimethyl-cyclohexanone

Guidance literature:: With methyllithium; acetyl chloride; Yield given. Multistep reaction; 1.) ether, rt.; 2.) THF, -78 deg C, 15 min, then 2 h;
DOI:10.1021/ja00294a046