(R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

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Chemical Name:(R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione
CAS No.:201732-43-6
Molecular Formula:C₃₂H₃₉N₃O₅Si
Molecular Weight:573.764
Hs Code.:

Synonyms:(R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

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Chemical Property of (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

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Technology Process of (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

There total 6 articles about (R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 201732-38-9
((R)-3-Benzyloxy-2-chloromethoxy-propoxy)-tert-butyl-diphenyl-silane

: 5-methyl-2,6-bis-trimethylsilanyloxy-pyrimidin-4-ylamine

: 201732-43-6
(R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

: 6-amino-1-[1-benzyloxymethyl-2-(tert-butyl-diphenyl-silanyloxy)-ethoxymethyl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tin(IV) chloride; In acetonitrile; at 0 - 25 ℃; for 1.16667h;
DOI:10.1016/S0040-4020(97)10289-7

Reference yield:

: 15828-63-4
6-aminothymine

: 201732-43-6
(R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 0.5 h / 20 °C

2: 48 percent / SnCl₄ / acetonitrile / 1.17 h / 0 - 25 °C

With tin(IV) chloride; In acetonitrile; 1: silylation / 2: glycosylation;
DOI:10.1016/S0040-4020(97)10289-7

Reference yield:

: 17325-85-8
(2S)-3-(benzyloxy)propane-1,2-diol

: 201732-43-6
(R)-4-amino-1-{[2-O-t-butyldiphenylsilyl-1-(benzyloxymethyl)ethoxy]methyl}-5-methyl-2,6-[1H,3H]-pyrimidione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / 4-dimethylaminopyridine; triethylamine / CH₂Cl₂ / 20 °C

2: HCl / CH₂Cl₂ / -4 - 0 °C

3: 48 percent / SnCl₄ / acetonitrile / 1.17 h / 0 - 25 °C

With hydrogenchloride; dmap; tin(IV) chloride; triethylamine; In dichloromethane; acetonitrile; 1: silylation / 2: Alkylation / 3: glycosylation;
DOI:10.1016/S0040-4020(97)10289-7