N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide

Base Information

• Chemical Name: N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide
• CAS No.: 1448807-10-0
• Molecular Formula: C₁₇H₁₀BrN₃O₃
• Molecular Weight: 384.189
• Mol file: 1448807-10-0.mol

Synonyms:N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide

Chemical Property of N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide

There total 3 articles about N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-furanoic acid (88-14-2) + 3-(6-bromooxazolo[4,5-b]pyridin-2-yl)aniline (1448807-28-0) → N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide (1448807-10-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 45 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.05.007

Reference yield:

2-amino-3-hydroxy-5-bromopyridine (39903-01-0) → N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide (1448807-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 4 h / 220 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 45 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.ejmech.2013.05.007

Reference yield:

meta-aminobenzoic acid (99-05-8,159139-79-4) → N-(3-(6-bromooxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide (1448807-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid / 4 h / 220 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 45 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.ejmech.2013.05.007

upstream raw materials:

2-amino-3-hydroxy-5-bromopyridine

2-furanoic acid

3-(6-bromooxazolo[4,5-b]pyridin-2-yl)aniline

meta-aminobenzoic acid

Downstream raw materials:

N-(3-(6-phenyloxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide

N-(3-(6-(4-chlorophenyl)oxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide

N-(3-(6-(4-methoxyphenyl)oxazolo[4,5-b]pyridin-2-yl)phenyl)furan-2-carboxamide