2-cyano-3-(2-iodophenyl)-2-propenethioamide

Base Information

• Chemical Name: 2-cyano-3-(2-iodophenyl)-2-propenethioamide
• CAS No.: 161689-29-8
• Molecular Formula: C₁₀H₇IN₂S
• Molecular Weight: 314.149
• Mol file: 161689-29-8.mol

Synonyms:2-cyano-3-(2-iodophenyl)-2-propenethioamide

Chemical Property of 2-cyano-3-(2-iodophenyl)-2-propenethioamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-cyano-3-(2-iodophenyl)-2-propenethioamide

There total 1 articles about 2-cyano-3-(2-iodophenyl)-2-propenethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Cyanothioacetamide (7357-70-2) + 2-iodobenzaldehyde (26260-02-6) → 2-cyano-3-(2-iodophenyl)-2-propenethioamide (161689-29-8)

Guidance literature:

With piperidine; In 1,4-dioxane; at 80 ℃;

DOI:10.1021/jm301575n

Reference yield: 43.0%

2-cyano-3-(2-iodophenyl)-2-propenethioamide (161689-29-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 4-(2-iodophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (1286771-75-2)

Guidance literature:

With piperidine; In 1,4-dioxane; at 80 ℃; for 2h;

DOI:10.1021/jm301575n

Reference yield:

2-cyano-3-(2-iodophenyl)-2-propenethioamide (161689-29-8) → [3-amino-4-(2-iodophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-yl](phenyl)methanone (1286771-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / 1,4-dioxane / 2 h / 80 °C

2: potassium hydroxide / N,N-dimethyl-formamide; water / 0.83 h / 20 °C / Enzymatic reaction

With piperidine; potassium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm301575n

upstream raw materials:

Cyanothioacetamide

2-iodobenzaldehyde

Downstream raw materials:

4-(2-iodophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

[3-amino-4-(2-iodophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-yl](phenyl)methanone

[3-amino-4-(2-iodophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-yl](4-chlorophenyl)methanone