methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate

Base Information

• Chemical Name: methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate
• CAS No.: 1415460-57-9
• Molecular Formula: C₁₉H₂₂N₂O₂
• Molecular Weight: 310.396
• Mol file: 1415460-57-9.mol

Synonyms:methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate

Chemical Property of methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate

There total 3 articles about methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-(2-iodobenzyl)-1,2,3,4-tetrahydroquinazoline (1415460-56-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate (1415460-57-9) + methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-4-yl)propanoate (1415460-58-0) + dimethyl 3,3'-(3-benzyl-1,2,3,4-tetrahydroquinazoline-2,4-diyl)dipropionate + 3-benzyl-1,2,3,4-tetrahydro-quinazoline (40132-09-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 16.2h; Time; Concentration; Solvent; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2014.12.067

Reference yield: 23.0%

3-(2-iodobenzyl)-1,2,3,4-tetrahydroquinazoline (1415460-56-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate (1415460-57-9) + methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-4-yl)propanoate (1415460-58-0) + dimethyl 3,3'-(3-benzyl-1,2,3,4-tetrahydroquinazoline-2,4-diyl)dipropionate

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 13h; Inert atmosphere;

DOI:10.1016/j.tet.2014.12.067

Reference yield: 15.0%

3-(2-iodobenzyl)-1,2,3,4-tetrahydroquinazoline (1415460-56-8) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate (1415460-57-9) + methyl 3-(3-benzyl-1,2,3,4-tetrahydroquinazolin-4-yl)propanoate (1415460-58-0) + C23H28N2O4 (1415460-59-1) + 3-benzyl-1,2,3,4-tetrahydro-quinazoline (40132-09-0)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; Inert atmosphere;

DOI:10.1021/ol3029912

upstream raw materials:

3-(2-iodobenzyl)-1,2,3,4-tetrahydroquinazoline

acrylic acid methyl ester