40132-09-0Relevant articles and documents
The development of carbon-carbon bond forming reactions of aminal radicals
Schiedler, David A.,Vellucci, Jessica K.,Lu, Yi,Beaudry, Christopher M.
, p. 1448 - 1465 (2015/02/19)
Aminal radicals were generated and used in synthetic reactions for the first time. Aminal radicals are formed from aminals by radical translocation using AIBN and a stoichiometric hydrogen atom donor, or by SmI2 reduction of N-acyl amidines or amidinium ions in the presence of a proton source. Aminal radicals were found to participate in inter- and intramolecular C-C bond forming reactions with electron deficient alkenes. Chemical yields were as high as 99%.
Synthesis and in vitro study of platelet antiaggregant activity of 1,2,3,4-tetrahydroquinazoline derivatives
Gravier,Dupin,Casadebaig,Hou,Boisseau,Bernard
, p. 531 - 535 (2007/10/02)
Some original 3-substituted 1,2,3,4-tetrahydroquinazolines were synthesized. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by the main inducers (ADP, collagen, arachidonic acid), platelet serotonin release reaction and thromboxane A2 synthesis. All these molecules possess an inhibiting power which, compared to that of aspirin in the same conditions, is the same or greater when aggregation is induced by ADP.
