N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide

Base Information

• Chemical Name: N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide
• CAS No.: 1053623-77-0
• Molecular Formula: C₇₃H₉₃NO₁₁
• Molecular Weight: 1160.54
• Mol file: 1053623-77-0.mol

Synonyms:N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide

Chemical Property of N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide

There total 1 articles about N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C81H101NO12 (1053616-32-2) → N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide (1053623-77-0)

Guidance literature:

With phosphate buffer; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jo00112a040

Reference yield:

N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide (1053623-77-0) → N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-oxo-decyl)-tetrahydro-pyran-3-yl]-acetamide (1054656-80-2)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; 3 A molecular sieve; In benzene; for 1h; Ambient temperature;

DOI:10.1021/jo00112a040

Reference yield:

N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-hydroxy-decyl)-tetrahydro-pyran-3-yl]-acetamide (1053623-77-0) → 10-{(2S,3S,4S,5R)-3-Acetylamino-4-benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-tetrahydro-pyran-2-yl}-decanoic acid (163041-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (PPh₃)3RuCl₂, 3 Angstroem molecular sieves / benzene / 1 h / Ambient temperature

2: 10percent aq. NaClO₂, 10percent aq. NaH₂PO₄*H₂O / 2-methyl-propan-2-ol; various solvent(s) / 0.17 h / Ambient temperature

With sodium chlorite; sodium dihydrogenphosphate; tris(triphenylphosphine)ruthenium(II) chloride; 3 A molecular sieve; In tert-butyl alcohol; benzene;

DOI:10.1021/jo00112a040

upstream raw materials:

C₈₁H₁₀₁NO₁₂

Downstream raw materials:

N-[(2S,3S,4S,5R)-4-Benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-2-(10-oxo-decyl)-tetrahydro-pyran-3-yl]-acetamide

10-{(2S,3S,4S,5R)-3-Acetylamino-4-benzyloxy-5-[(2S,3S,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3R,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-tetrahydro-pyran-2-ylmethyl]-tetrahydro-pyran-2-yl}-decanoic acid