methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

Base Information

Chemical Name:methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate
CAS No.:1414357-79-1
Molecular Formula:C₂₇H₄₂N₆O₆
Molecular Weight:546.667
Hs Code.:

Synonyms:methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

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Chemical Property of methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

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Technology Process of methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

There total 4 articles about methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 1414357-76-8
methyl (S)-2-[(S)-2-amino-6-azidohexanamido]-3-phenylpropanoate hydrochloride

: 1414357-79-1
methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

Guidance literature:: With 1,2,3-Benzotriazole; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In acetonitrile; at 0 - 20 ℃;
DOI:10.1055/s-0032-1316702

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 1414357-79-1
methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; benzotriazol-1-yl-sulfonyl azide / water; acetonitrile / 6 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

3: hydrogenchloride / methanol / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

With hydrogenchloride; 1,2,3-Benzotriazole; benzotriazol-1-yl-sulfonyl azide; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; water; acetonitrile;
DOI:10.1055/s-0032-1316702

Reference yield:

: 846549-33-5
dicyclohexylammonium N-tert-butyloxycarbonyl-2-amino-6-azidohexanoate

: 1414357-79-1
methyl (2S,5S,8S)-5-(4-azidobutyl)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-10-methyl-4,7-dioxo-3,6-diazaundecanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

2: hydrogenchloride / methanol / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; 1,2,3-Benzotriazole / acetonitrile / 0 - 20 °C

With hydrogenchloride; 1,2,3-Benzotriazole; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1055/s-0032-1316702