4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide

Base Information

Chemical Name:4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide
CAS No.:943780-31-2
Molecular Formula:C₃₃H₃₂N₆O₂S
Molecular Weight:576.722
Hs Code.:

Synonyms:4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide

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Chemical Property of 4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide

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Technology Process of 4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide

There total 2 articles about 4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 943780-88-9
C₂₃H₂₁N₅O₂S

: 213924-62-0
(1-amino-2,3-dihydro-1H-inden-1-yl)methanol

: 943780-31-2
4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;

Reference yield:

: 3927-71-7
1-amino-2,3-dihydro-1H-indene-1-carboxylic acid

: 943780-31-2
4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol; water / 4 h / Heating / reflux

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 20 °C

With sodium tetrahydroborate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In ethanol; water; dimethyl sulfoxide;