(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

Base Information

Chemical Name:(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate
CAS No.:1381841-52-6
Molecular Formula:C₂₅H₃₀F₂N₆O₄S
Molecular Weight:548.614
Hs Code.:

(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

Synonyms:(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

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Chemical Property of (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

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Technology Process of (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

There total 18 articles about (1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₄F₂N₆O₄S

: 1381841-52-6
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

Guidance literature:: With iodine; In methanol; at 60 ℃; for 4h;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 145783-15-9
4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine

: 1381841-52-6
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; sodium iodide / 1,4-dioxane / 120 °C

2.1: sodium nitrite / water; acetic acid; ethyl acetate

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane

4.1: triethylamine / acetonitrile / 0.5 h / 20 °C

4.2: 2 h / 20 °C

5.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050

Reference yield:

: 1006614-49-8,220352-38-5,1459719-81-3
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

: 1381841-52-6
(1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino-5-propylthio-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyl butyrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane

2.1: triethylamine / acetonitrile / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: iodine / methanol / 4 h / 60 °C

With iodine; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.04.050