(2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

Base Information

Chemical Name:(2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride
CAS No.:951401-49-3
Molecular Formula:C₁₆H₁₇F₂NOS*ClH
Molecular Weight:345.841
Hs Code.:

Synonyms:(2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

Chemical Property:

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Technology Process of (2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

There total 2 articles about (2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 951401-11-9
[(1S,2S)-1-(3,5-difluoro-benzyl)-2-hydroxy-3-phenylsulfanyl-propyl]-carbamic acid tert-butyl ester

: 951401-49-3
(2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

Guidance literature:: [(1S,2S)-1-(3,5-difluoro-benzyl)-2-hydroxy-3-phenylsulfanyl-propyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield:

: 108-98-5
thiophenol

: 951401-49-3
(2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 0.5 h / Heating / reflux

2: trifluoroacetic acid

With triethylamine; trifluoroacetic acid; In methanol;

Reference yield:

: 2466-76-4
N-Acetylimidazole

: 951401-49-3
(2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride

: 951401-53-9
C₁₈H₁₉F₂NO₂S

Guidance literature:: N-Acetylimidazole; (2S,3S)-3-amino-4-(3,5-difluoro-phenyl)-1-phenylsulfanyl-butan-2-ol hydrochloride; In dichloromethane; at 20 ℃; for 1h;

With triethylamine; at 20 ℃; for 73h; Heating / reflux;