Chemical Property of N-Acetylimidazole
Chemical Property:
- Appearance/Colour:white to beige or light tan adhering crystals
- Vapor Pressure:0.104mmHg at 25°C
- Melting Point:99-105 °C(lit.)
- Refractive Index:1.552
- Boiling Point:221.955 °C at 760 mmHg
- PKA:pKa 3.6(H2O,t = 25,I=0.2) (Uncertain)
- Flash Point:88.035 °C
- PSA：34.89000
- Density:1.146 g/cm3
- LogP:0.54320
- Storage Temp.:Store at 0
- Sensitive.:Moisture Sensitive
- Solubility.:water: soluble50mg/mL, clear, colorless
- Water Solubility.:Hydrolyzes in water. Solubility in methanol (almost transparency).
- XLogP3:-0.3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:110.048012819
- Heavy Atom Count:8
- Complexity:103
- Purity/Quality:
-
99% *data from raw suppliers
1-Acetylimidazole *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
36/37/38
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(=O)N1C=CN=C1
-
Uses
Acetylating agent for capping unreacted amino groups in peptide synthesis. It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives. Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.
