3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

Base Information

Chemical Name:3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione
CAS No.:862468-85-7
Molecular Formula:C₂₀H₂₁BrN₄O₃
Molecular Weight:445.316
Hs Code.:

Synonyms:3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

Suppliers and Price of 3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

There total 4 articles about 3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862468-65-3
3-benzyl-1-propyl-3,7-dihydropurine-2,6-dione

: 862468-85-7
3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / CH₃CO₂Na; Br₂; acetic acid / 1 h / 45 °C

2.1: K₂CO₃ / dimethylformamide / 0.08 h / 20 °C

2.2: 83 percent / dimethylformamide / 20 °C

With bromine; sodium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm058008c

Reference yield:

: 200557-53-5
6-amino-1-benzyl-3-propylpyrimidine-2,4(1H,3H)-dione

: 862468-85-7
3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂; CH₃COOH / ethanol / 0.5 h / 40 °C

2.1: aq. Na₂S₂O₄ / 0.5 h / 85 °C

3.1: 1 h / Heating

3.2: 90 percent / aq. NaOH / ethanol / 1 h / Heating

4.1: 90 percent / CH₃CO₂Na; Br₂; acetic acid / 1 h / 45 °C

5.1: K₂CO₃ / dimethylformamide / 0.08 h / 20 °C

5.2: 83 percent / dimethylformamide / 20 °C

With sodium dithionite; bromine; sodium acetate; potassium carbonate; acetic acid; sodium nitrite; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm058008c

Reference yield:

: 200557-55-7
5,6-diamino-1-benzyl-3-propylpyrimidine-2,4(1H,3H)-dione

: 862468-85-7
3-benzyl-8-bromo-7-(2-cyclopropyl-2-oxoethyl)-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1 h / Heating

1.2: 90 percent / aq. NaOH / ethanol / 1 h / Heating

2.1: 90 percent / CH₃CO₂Na; Br₂; acetic acid / 1 h / 45 °C

3.1: K₂CO₃ / dimethylformamide / 0.08 h / 20 °C

3.2: 83 percent / dimethylformamide / 20 °C

With bromine; sodium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm058008c