10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene

Base Information

Chemical Name:10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene
CAS No.:239066-72-9
Molecular Formula:C₂₆H₂₅NO₂
Molecular Weight:383.49
Hs Code.:
DSSTox Substance ID:DTXSID501133596
Nikkaji Number:J1.596.752H
Pharos Ligand ID:TYPCXGY37JW5
ChEMBL ID:CHEMBL99046

Synonyms:CHEMBL99046;SCHEMBL4171493;DTXSID501133596;BDBM50103246;10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene;10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene;2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-phenyl-1h-[1]benzopyrano[3,4-f]quinoline;239066-72-9

Suppliers and Price of 10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene

Chemical Property:

XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:383.188529040
Heavy Atom Count:29
Complexity:622

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(NC2=C1C3=C(C=C2)C4=C(C=CC=C4OC)OC3C5=CC=CC=C5)(C)C

Technology Process of 10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene

There total 9 articles about 10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-1-aza-6-oxachrysene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 239070-98-5
10-methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-5-ol

: 239066-72-9
(+/-)-2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-phenyl-1H-[1]benzopyrano[3,4-f]quinoline

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm010228c

Reference yield:

: 6942-36-5
methyl 2-bromo-5-nitrobenzoate

: 239066-72-9
(+/-)-2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-phenyl-1H-[1]benzopyrano[3,4-f]quinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / cesium carbonate / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 24 h / 100 °C

2: 96 percent / boron tribromide / CH₂Cl₂ / -78 - 23 °C

3: 99 percent / cesium carbonate / dimethylformamide / 4 h / 23 °C

4: 98 percent / H₂ / Pd/C / dioxane / 60 h / 65 °C / atmospheric pressure

5: 47 percent / iodine / 48 h / 105 °C

6: 62 percent / tetrahydrofuran; cyclohexane; diethyl ether / 2 h / -50 °C

7: 86 percent / triethylsilane; boron trifluoride diethyl etherate / CH₂Cl₂ / 16 h / 20 °C

With triethylsilane; boron trifluoride diethyl etherate; hydrogen; iodine; boron tribromide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm010228c

Reference yield:

: 23112-96-1
(2,6-dimethoxyphenyl)boronic acid

: 239066-72-9
(+/-)-2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-phenyl-1H-[1]benzopyrano[3,4-f]quinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / cesium carbonate / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 24 h / 100 °C

2: 96 percent / boron tribromide / CH₂Cl₂ / -78 - 23 °C

3: 99 percent / cesium carbonate / dimethylformamide / 4 h / 23 °C

4: 98 percent / H₂ / Pd/C / dioxane / 60 h / 65 °C / atmospheric pressure

5: 47 percent / iodine / 48 h / 105 °C

6: 62 percent / tetrahydrofuran; cyclohexane; diethyl ether / 2 h / -50 °C

7: 86 percent / triethylsilane; boron trifluoride diethyl etherate / CH₂Cl₂ / 16 h / 20 °C

With triethylsilane; boron trifluoride diethyl etherate; hydrogen; iodine; boron tribromide; caesium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm010228c