tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate
CAS No.:1301611-66-4
Molecular Formula:C₃₁H₃₅N₃O₆S
Molecular Weight:577.701
Hs Code.:

Synonyms:tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

There total 4 articles about tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1301611-61-9
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

: 1301611-66-4
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

: 1301611-64-2
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With Oxone; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

: 1301610-61-6
2-methylthio-5-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 1301611-66-4
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

: 1301611-64-2
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; potassium acetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

2: sodium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Reflux

4: Oxone / water; tetrahydrofuran; methanol / 20 °C

With Oxone; N-Bromosuccinimide; potassium acetate; potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1301610-69-4
6-bromo-2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 1301611-66-4
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfinyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

: 1301611-64-2
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylsulfonyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Reflux

3: Oxone / water; tetrahydrofuran; methanol / 20 °C

With Oxone; potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;