tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate
CAS No.:1301611-61-9
Molecular Formula:C₃₁H₃₅N₃O₅S
Molecular Weight:561.702
Hs Code.:

Synonyms:tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

There total 5 articles about tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1301611-59-5
6-bromo-3-(2-methoxyethyl)-2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-4(3H)-one

: 1301611-61-9
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; Reflux;

Reference yield:

: 10428-49-6
β-chloro-β-nitrostyrene

: 1301611-61-9
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 96 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide; potassium acetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

3: sodium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Reflux

With N-Bromosuccinimide; potassium acetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1979-98-2
2,4-dihydroxy-2-methylmercaptopyrimidine (hydroxy-keto form)

: 1301611-61-9
tert-butyl 1-(4-(3-(2-methoxyethyl)-2-(methylthio)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 96 h / Inert atmosphere; Reflux

2: N-Bromosuccinimide; potassium acetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere; Sealed tube

3: sodium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Reflux

With N-Bromosuccinimide; potassium acetate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;