6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine

Base Information

• Chemical Name: 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine
• CAS No.: 102634-81-1
• Molecular Formula: C₁₅H₉F₃N₆
• Molecular Weight: 330.272
• Mol file: 102634-81-1.mol

Synonyms:6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine

Chemical Property of 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine

There total 3 articles about 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-hydrazino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazine monohydrochloride (102618-11-1) + trifluoroacetic anhydride (407-25-0) → 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine (102634-81-1)

Guidance literature:

With potassium acetate; In trifluoroacetic acid; at 100 ℃; for 4h;

DOI:10.1002/jhet.5570220424

Reference yield:

3-chloro-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazine (102618-10-0) → 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine (102634-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 g / N₂H₄*H₂O / butan-1-ol / 3 h / Heating

2: 50 percent / CH₃COOK / trifluoroacetic acid / 4 h / 100 °C

With potassium acetate; hydrazine hydrate; In trifluoroacetic acid; butan-1-ol;

DOI:10.1002/jhet.5570220424

Reference yield:

6-<4-(1H-imidazole-1-yl)phenyl>-3(2H)-pyridazinone (84243-59-4) → 6-<4-(1H-imidazol-1-yl)phenyl>-3-(trifluoromethyl)-1,2,4-triazolo<4,3-b>pyridazine (102634-81-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 12 g / POCl₃ / 3 h / 90 - 92 °C

2: 1 g / N₂H₄*H₂O / butan-1-ol / 3 h / Heating

3: 50 percent / CH₃COOK / trifluoroacetic acid / 4 h / 100 °C

With potassium acetate; hydrazine hydrate; trichlorophosphate; In trifluoroacetic acid; butan-1-ol;

DOI:10.1002/jhet.5570220424

upstream raw materials:

3-hydrazino-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazine monohydrochloride

trifluoroacetic anhydride

3-chloro-6-<4-(1H-imidazol-1-yl)phenyl>-3(2H)-pyridazine

6-<4-(1H-imidazole-1-yl)phenyl>-3(2H)-pyridazinone