2-Hydrazino-6-methoxypyridine

Base Information

• Chemical Name: 2-Hydrazino-6-methoxypyridine
• CAS No.: 74677-60-4
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.157
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20579147
• Wikidata: Q82469568
• Mol file: 74677-60-4.mol

Synonyms:74677-60-4;2-HYDRAZINO-6-METHOXYPYRIDINE;2-HYDRAZINYL-6-METHOXYPYRIDINE;(6-methoxypyridin-2-yl)hydrazine;1-(6-METHOXYPYRIDIN-2-YL)HYDRAZINE;MFCD09863247;2(1H)-Pyridinone, 6-methoxy-, hydrazone;6-Methoxy-2-hydrazinopyridine;SCHEMBL6071585;DTXSID20579147;BYKHMSRXEDLDRS-UHFFFAOYSA-N;AKOS012898419;SY356840;CS-0205822;F16103;EN300-1687771

Chemical Property of 2-Hydrazino-6-methoxypyridine

Chemical Property:

• Boiling Point: 283.8±50.0 °C(Predicted)
• PKA: 9.31±0.70(Predicted)
• PSA: 60.17000
• Density: 1.23±0.1 g/cm3(Predicted)
• LogP: 1.14910
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 139.074561919
• Heavy Atom Count: 10
• Complexity: 99

Purity/Quality:

95% ^*data from raw suppliers

2-hydrazino-6-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=N1)NN

Technology Process of 2-Hydrazino-6-methoxypyridine

There total 2 articles about 2-Hydrazino-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

6-chloro-2-methoxypyridine (17228-64-7) → (6-methoxy-pyridin-2-yl)-hydrazine (74677-60-4)

Guidance literature:

With hydrazine hydrate; at 160 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/ol902139r

Reference yield: 41.0%

6-bromo-2-methoxypyridine (40473-07-2) → (6-methoxy-pyridin-2-yl)-hydrazine (74677-60-4)

Guidance literature:

With hydrazine hydrate; at 120 ℃; for 3.5h;

DOI:10.1016/j.ejmech.2021.113232

Reference yield:

phenylacetaldehyde (122-78-1) + (6-methoxy-pyridin-2-yl)-hydrazine (74677-60-4) → C14H15N3O

Guidance literature:

In toluene; Dean-Stark apparatus;

upstream raw materials:

6-chloro-2-methoxypyridine

6-bromo-2-methoxypyridine

Downstream raw materials:

C₂₇H₂₄Cl₂F₃N₇O₃

C₂₂H₁₆Cl₂F₃N₇O