benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

Base Information

Chemical Name:benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate
CAS No.:1357196-23-6
Molecular Formula:C₂₄H₂₁N₃O₅
Molecular Weight:431.448
Hs Code.:

Synonyms:benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

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Chemical Property of benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

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Technology Process of benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

There total 7 articles about benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357196-18-9
benzyl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)benzoate

: 105-36-2
ethyl bromoacetate

: benzyl 4-[4-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

: 1357196-23-6
benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 15128-82-2
3-hydroxy-2-nitropyridine

: benzyl 4-[4-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

: 1357196-23-6
benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

1.2: 72 h / Reflux; oil bath

2.1: potassium phosphate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 24 h / 90 °C

3.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

4.1: triethylamine / tetrahydrofuran / 72 h / 20 °C

5.1: water; lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; water; hydrogen; sodium hydride; potassium carbonate; triethylamine; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 146336-72-3
2-nitro-3-(trifluoromethylsulfonyloxy)pyridine

: benzyl 4-[4-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

: 1357196-23-6
benzyl 4-[3-(2-ethoxy-2-oxoethyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene / 24 h / 90 °C

2: hydrogen / palladium on activated charcoal / methanol / 20 °C

3: triethylamine / tetrahydrofuran / 72 h / 20 °C

4: water; lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; water; hydrogen; potassium carbonate; triethylamine; lithium hydroxide; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;