3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:1287264-33-8
Molecular Formula:C₃₃H₂₈N₂O₄
Molecular Weight:516.596
Hs Code.:

Synonyms:3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about 3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287264-25-8
{2-[(2-chloroacetyl)-(1-phenylethyl)amino]ethyl}carbamic acid tert-butyl ester

: 1287264-33-8
3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 24 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -35 °C

3.2: 24 h / 20 °C

4.1: acetonitrile / 12 h / Reflux

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/jm200138r

Reference yield:

: 1287264-28-1
3-oxo-4-(1-phenylethyl)piperazine-1-carboxylic acid tert-butyl ester

: 1287264-33-8
3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -35 °C

2.2: 24 h / 20 °C

3.1: acetonitrile / 12 h / Reflux

With lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jm200138r

Reference yield:

: 944256-02-4
4-(1-phenylethyl)piperazine carboxylic acid tert-butyl ester

: 1287264-33-8
3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -35 °C

1.2: 24 h / 20 °C

2.1: acetonitrile / 12 h / Reflux

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/jm200138r