944256-02-4

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 773848-51-4 1-[(R)-1-phenylethyl]piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 1287264-25-8 {2-[(2-chloroacetyl)-(1-phenylethyl)amino]ethyl}carbamic acid tert-butyl ester 
• 622373-29-9 [2-(1-phenylethylamino)ethyl]carbamic acid tert-butyl ester 
• 1287264-28-1 3-oxo-4-(1-phenylethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1287264-24-7 [(1-phenylethylcarbamoyl)methyl]carbamic acid tert-butyl ester 
• 4530-20-5 BOC-glycine 
• 1076195-93-1 (S)-1-(phenyl)ethyl methanesulfonate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1287264-37-2 (S)-1,1-diphenyl-7-((S)-1-phenylethyl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one 
• 1287264-32-7 (R)-1,1-diphenyl-7-((S)-1-phenylethyl)tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one 
• 1287264-33-8 3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 1287264-39-4 3-oxo-1,1-diphenyltetrahydrooxazolo[ 3,4-a]pyrazine-7-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 847555-74-2 (R)-SHA 68 
• 847555-75-3 (S)-SHA 68 
• 773848-51-4 1-[(R)-1-phenylethyl]piperazine 

Relevant academic research and scientific papers

Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent

A new method for the synthesis of enantiopure α-substituted piperazines via direct functionalization of the intact piperazine ring is described. The approach utilizes the asymmetric lithiation-substitution of an α-methylbenzyl-functionalized N-Boc piperaz

Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9 R/S)-3-Oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4- a ]pyrazine-7-carboxylic Acid 4-fluoro-benzylamide (SHA 68)

This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of the neuropeptide S receptor (NPSR) antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine- 7-carboxylic acid 4-fluoro-be

Urotensin II receptor antagonists

This invention is directed to a compound of Formula (I): and forms thereof, wherein A, B, E, G, X and L2 are as defined herein and their use as urotensin II receptor antagonists.

UROTENSIN II RECEPTOR ANTAGONISTS

The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.