2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

Base Information

Chemical Name:2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole
CAS No.:1310689-27-0
Molecular Formula:C₂₁H₂₄FN₃O
Molecular Weight:352.441
Hs Code.:

2-[4-(4-<sup>(18)</sup>F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

Synonyms:2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

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Chemical Property of 2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

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Technology Process of 2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

There total 4 articles about 2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310689-26-9
[1-(5-methoxybenzimidazol)-2-ylmethylpiperidin-4-yl]-(4-⁽¹⁸⁾F-fluorophenyl)methanone

: 1310689-27-0
2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

Guidance literature:: With triethylsilane; trifluorormethanesulfonic acid; at 105 ℃; for 0.0833333h;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-21-4
[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-yl]-(4-nitrophenyl)methanone

: 1310689-27-0
2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / dimethyl sulfoxide / 0.25 h / 140 °C / Sealed vial

2: triethylsilane; trifluorormethanesulfonic acid / 0.08 h / 105 °C

With triethylsilane; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; trifluorormethanesulfonic acid; In dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 145851-04-3
(4-nitrophenyl)(piperidin-4-yl)methanone

: 1310689-27-0
2-[4-(4-⁽¹⁸⁾F-fluorobenzyl)piperidin-1-yl]methyl-5-methoxybenzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / acetonitrile / 72 h / 45 °C / Inert atmosphere

2: 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride / dimethyl sulfoxide / 0.25 h / 140 °C / Sealed vial

3: triethylsilane; trifluorormethanesulfonic acid / 0.08 h / 105 °C

With triethylsilane; 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; trifluorormethanesulfonic acid; sodium carbonate; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.013