ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Base Information

• Chemical Name: ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
• CAS No.: 107752-85-2
• Molecular Formula: C₁₈H₁₉NO₄
• Molecular Weight: 313.353
• Mol file: 107752-85-2.mol

Synonyms:2-amino-5,6,7,8-tetrahydro-5-oxo-4-phenyl-4H-benzo--pyran-3-ethylcarboxylate

Chemical Property of ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Chemical Property:

• Melting Point: 180 °C(Solv: ethanol (64-17-5))
• Boiling Point: 519.0±50.0 °C(Predicted)
• PKA: 3.53±0.40(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate ^*data from reagent suppliers

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Technology Process of ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

There total 9 articles about ethyl 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,3-cylohexanedione (504-02-9) + ethyl benzylidenecyanoacetate (2025-40-3) → 2-amino-5,6,7,8-tetrahydro-5-oxo-4-phenyl-4H-benzo--pyran-3-ethylcarboxylate (107752-85-2)

Guidance literature:

With cobalt(II) diacetate tetrahydrate; (R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201001151

Reference yield: 93.0%

1,3-cylohexanedione (504-02-9) + benzaldehyde (100-52-7) + ethyl 2-cyanoacetate (105-56-6) → 2-amino-5,6,7,8-tetrahydro-5-oxo-4-phenyl-4H-benzo--pyran-3-ethylcarboxylate (107752-85-2)

Guidance literature:

With ascorbic acid; In water; at 35 - 40 ℃; for 0.283333h; Irradiation; Green chemistry;

DOI:10.1080/00304948.2021.1935149

Reference yield: 92.0%

(Z)-ethyl 2-cyano-3-phenylacrylate (14533-87-0) + 1,3-Cyclohexanedione (30182-67-3) → 2-amino-5,6,7,8-tetrahydro-5-oxo-4-phenyl-4H-benzo--pyran-3-ethylcarboxylate (107752-85-2)

Guidance literature:

With acetic acid; In acetonitrile; for 0.5h; Heating;

DOI:10.1016/0040-4020(96)00879-4

upstream raw materials:

ethyl (E)-2-cyano-3-phenyl-2-propenoate

1,3-cylohexanedione

2-phenyl-4,4,6-trimethyltetrahydro-(2H)-1,3-oxazine

1,3-Cyclohexanedione

Downstream raw materials:

C₁₈H₁₅NO₄

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