3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

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Chemical Name:3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione
CAS No.:830346-44-6
Molecular Formula:C₃₂H₃₀ClF₄N₃O₅
Molecular Weight:648.054
Hs Code.:

Synonyms:3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

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Chemical Property of 3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

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Technology Process of 3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

There total 4 articles about 3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 830346-43-5
5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

: 102089-75-8
(-)-(1R)-1-[(1',1'-dimethylethoxycarbonyl)amino]-2-(methylsulfonyl)oxy-1-phenylethane

: 830346-44-6
3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 75 ℃; for 16h;

Reference yield:

: 830346-32-2
5-bromo-1-[2-fluoro-6-(trifluoromethyl)benzyl]pyrimidine-2,4-(1H,3H)-dione

: 830346-44-6
3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / DEAD; Ph₃P / tetrahydrofuran

2: aq. Na₂CO₃; Pd[PPh₃]4 / dioxane / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.03.057

Reference yield:

: 239087-08-2
2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

: 830346-44-6
3-[2(R)-{tert-butoxycarbonylamino}-2-phenylethyl]-5-(2-chloro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)-benzyl]pyrimidine-2,4-(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / N,O-bis(trimethylsilyl)acetamide / acetonitrile / 80 °C

2: 91 percent / DEAD; Ph₃P / tetrahydrofuran

3: aq. Na₂CO₃; Pd[PPh₃]4 / dioxane / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,O-bis-(trimethylsilyl)-acetamide; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; acetonitrile; 2: Mitsunobu reaction / 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.03.057