Boc-His(Tos)Leu-ΨCSNH-Met-OMet

Base Information

Chemical Name:Boc-His(Tos)Leu-ΨCSNH-Met-OMet
CAS No.:145641-55-0
Molecular Formula:C₃₀H₄₅N₅O₇S₃
Molecular Weight:683.915
Hs Code.:

Synonyms:Boc-His(Tos)Leu-ΨCSNH-Met-OMet

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Chemical Property of Boc-His(Tos)Leu-ΨCSNH-Met-OMet

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Technology Process of Boc-His(Tos)Leu-ΨCSNH-Met-OMet

There total 9 articles about Boc-His(Tos)Leu-ΨCSNH-Met-OMet which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: (S)-2-((S)-2-Amino-4-methyl-pentanethioylamino)-4-methylsulfanyl-butyric acid methyl ester

: C₂₃H₃₁N₃O₈S

: 145641-55-0
Boc-His(Tos)Leu-ΨCSNH-Met-OMet

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; 1) -10 deg C to r. t., 2 h, 2) r. t., 4 h;
DOI:10.1016/S0040-4020(01)89436-9

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 145641-55-0
Boc-His(Tos)Leu-ΨCSNH-Met-OMet

Guidance literature:: Multi-step reaction with 7 steps

1: 1) N-methylmorpholine, i-BuOCOCl / 1) THF, -10 deg C, 15 min, 2a) 1 atm, -10 deg C to 0 deg C, 2 h, b) r. t., 3 h

2: 91 percent / Lawesson's Reagent / benzene / Heating

3: acetonitrile / 48 h

4: 1) H₂S / ethanol / 1) 0 deg C, 1 h, 2) 0 deg C, overnight

5: triethylammonium hydroxybenzotriazolate / acetonitrile / 48 h

6: 4 N HCl / dioxane / 760 Torr / 1) 0 deg C, 5 min, 2) r. t., 25 min

7: 68 percent / N-methylmorpholine / tetrahydrofuran / 1) -10 deg C to r. t., 2 h, 2) r. t., 4 h

With Lawessons reagent; 4-methyl-morpholine; hydrogenchloride; triethylammonium hydroxybenzotriazolate; hydrogen sulfide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile; benzene;
DOI:10.1016/S0040-4020(01)89436-9

Reference yield:

: 2280-69-5
Boc-Leu-Met-OMe

: 145641-55-0
Boc-His(Tos)Leu-ΨCSNH-Met-OMet

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Lawesson's Reagent / benzene / 2 h / Heating

2: 4 N HCl / dioxane / 760 Torr / 1) 0 deg C, 5 min, 2) r. t., 25 min

3: 68 percent / N-methylmorpholine / tetrahydrofuran / 1) -10 deg C to r. t., 2 h, 2) r. t., 4 h

With Lawessons reagent; 4-methyl-morpholine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; benzene;
DOI:10.1016/S0040-4020(01)89436-9