N₁-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N₂-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N₁-methylethane-1,2-diamine

Base Information

• Chemical Name: N₁-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N₂-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N₁-methylethane-1,2-diamine
• CAS No.: 1356010-54-2
• Molecular Formula: C₂₇H₃₀ClFN₈O
• Molecular Weight: 537.04

Synonyms:N₁-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N₂-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N₁-methylethane-1,2-diamine

Chemical Property of N₁-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N₂-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N₁-methylethane-1,2-diamine

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Technology Process of N₁-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N₂-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N₁-methylethane-1,2-diamine

There total 15 articles about N₁-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N₂-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N₁-methylethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N1-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N2-methyl-N2-(2-(2-(3-methyl-1H-1,2,4-triazol-1-yl)-5-nitrophenoxy)ethyl)ethane-1,2-diamine (1356009-85-2) → N1-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N1-methylethane-1,2-diamine (1356010-54-2)

Guidance literature:

With iron; ammonium chloride; In methanol; water; at 65 ℃; for 2h;

Reference yield:

cyclopentanone (120-92-3) → N1-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N1-methylethane-1,2-diamine (1356010-54-2)

Guidance literature:

Multi-step reaction with 8 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

7: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

8: ammonium chloride; iron / water; methanol / 2 h / 65 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

4-flourophenylmagnesium bromide (352-13-6) → N1-(2-(5-amino-2-(3-methyl-1H-1,2,4-triazol-1-yl)phenoxy)ethyl)-N2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N1-methylethane-1,2-diamine (1356010-54-2)

Guidance literature:

Multi-step reaction with 8 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

7: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

8: ammonium chloride; iron / water; methanol / 2 h / 65 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

cyclopentanone

4-flourophenylmagnesium bromide

2-chloro-5-nitroanisole

5-nitro-2-chlorophenol

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