pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

Base Information

Chemical Name:pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester
CAS No.:292616-85-4
Molecular Formula:C₃₁H₃₆O₃Si
Molecular Weight:484.711
Hs Code.:

pent-4-ynoic acid 2-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

Synonyms:pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

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Chemical Property of pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

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Technology Process of pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

There total 3 articles about pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 292616-84-3
pent-4-ynoic acid 2-iodo-benzyl ester

: 136787-49-0
3-(tert-butyldiphenylsilyloxy)prop-1-ene

: 292616-85-4
pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

Guidance literature:: 3-(tert-butyldiphenylsilyloxy)prop-1-ene; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 23 ℃; for 1.5h;

pent-4-ynoic acid 2-iodo-benzyl ester; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenyl-arsane; In tetrahydrofuran; water; N,N-dimethyl-formamide; for 1h; Further stages.;
DOI:10.1021/ol0062547

Reference yield:

: 6089-09-4
4-pentynoic acid

: 292616-85-4
pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / DEAD; PPh₃ / tetrahydrofuran / 1 h / 23 °C

2.1: 9-BBN / tetrahydrofuran / 1.5 h / 23 °C

2.2: 50 percent / AsPh₃; Pd(dppf)Cl₂; CsCO₃ / tetrahydrofuran; dimethylformamide; H₂O / 1 h

With 9-borabicyclo[3.3.1]nonane dimer; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1.1: Esterification / 2.1: Addition / 2.2: Addition;
DOI:10.1021/ol0062547

Reference yield:

: 5159-41-1
2-iodobenzyl alcohol

: 292616-85-4
pent-4-ynoic acid 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / DEAD; PPh₃ / tetrahydrofuran / 1 h / 23 °C

2.1: 9-BBN / tetrahydrofuran / 1.5 h / 23 °C

2.2: 50 percent / AsPh₃; Pd(dppf)Cl₂; CsCO₃ / tetrahydrofuran; dimethylformamide; H₂O / 1 h

With 9-borabicyclo[3.3.1]nonane dimer; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1.1: Esterification / 2.1: Addition / 2.2: Addition;
DOI:10.1021/ol0062547