rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one
CAS No.:1352126-32-9
Molecular Formula:C₁₈H₂₀N₄O₂
Molecular Weight:324.382
Hs Code.:

Synonyms:rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

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Chemical Property of rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

There total 9 articles about rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 445264-60-8
3-methoxy-5-pyridineboronic acid pinacol ester

: 1352126-40-9
rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

: 1352126-32-9
rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine);

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352126-32-9
rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride; water / 18 h / Reflux

3.1: thionyl chloride / 18 h / 0 °C / Reflux

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: ethanol / 3 h / 20 - 70 °C / sealed tube

6.1: dichloromethane / 60 h / 20 °C

6.2: 0 °C

7.1: ammonium chloride / methanol / 18 h / 20 - 85 °C / sealed tube; Inert atmosphere

8.1: potassium phosphate / trans-diacetylpalladium(II) bis(dicyclohexylamine)

With hydrogenchloride; potassium phosphate; thionyl chloride; ammonia; water; ammonium chloride; triethylamine; trans-diacetylpalladium(II) bis(dicyclohexylamine); In methanol; ethanol; dichloromethane;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352126-32-9
rac-5-amino-3-[3-(5-methoxypyridin-3-yl)phenyl]-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / 18 h / Reflux

2.1: thionyl chloride / 18 h / 0 °C / Reflux

3.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4.1: ethanol / 3 h / 20 - 70 °C / sealed tube

5.1: dichloromethane / 60 h / 20 °C

5.2: 0 °C

6.1: ammonium chloride / methanol / 18 h / 20 - 85 °C / sealed tube; Inert atmosphere

7.1: potassium phosphate / trans-diacetylpalladium(II) bis(dicyclohexylamine)

With hydrogenchloride; potassium phosphate; thionyl chloride; water; ammonium chloride; triethylamine; trans-diacetylpalladium(II) bis(dicyclohexylamine); In methanol; ethanol; dichloromethane;