rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Base Information

Chemical Name:rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one
CAS No.:1352126-40-9
Molecular Formula:C₁₂H₁₄BrN₃O
Molecular Weight:296.167
Hs Code.:

Synonyms:rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

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Chemical Property of rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

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Technology Process of rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

There total 8 articles about rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1352126-41-0
rac-3-(3-bromophenyl)-1,3-dimethyl-5-thioxopiperazine-2-one

: 1352126-40-9
rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: With ammonium hydroxide; In water; at 50 ℃; for 18h; sealed tube;

Reference yield:

: 1352126-39-6
rac-3-(3-bromophenyl)-5-methoxy-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

: 1352126-40-9
rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: rac-3-(3-bromophenyl)-5-methoxy-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one; With ammonium chloride; In methanol; at 20 - 85 ℃; for 18h; sealed tube; Inert atmosphere;

With sodium carbonate; In methanol; water;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352126-40-9
rac-5-amino-3-(3-bromophenyl)-1,3-dimethyl-3,6-dihydro-1H-pyrazin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia; ammonium chloride / methanol / 96 h / 20 °C

2.1: hydrogenchloride; water / 18 h / Reflux

3.1: thionyl chloride / 18 h / 0 °C / Reflux

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: ethanol / 3 h / 20 - 70 °C / sealed tube

6.1: dichloromethane / 60 h / 20 °C

6.2: 0 °C

7.1: ammonium chloride / methanol / 18 h / 20 - 85 °C / sealed tube; Inert atmosphere

With hydrogenchloride; thionyl chloride; ammonia; water; ammonium chloride; triethylamine; In methanol; ethanol; dichloromethane;