N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

Base Information

Chemical Name:N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide
CAS No.:1354721-62-2
Molecular Formula:C₃₇H₃₉F₃N₆O₄S
Molecular Weight:720.816
Hs Code.:

Synonyms:N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

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Chemical Property of N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

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Technology Process of N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

There total 10 articles about N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1354721-87-1
3-(methyl-(2-morpholinoethyl)carbamoyl)benzoyl chloride

: 2-amino-5-(piperidin-1-yl)-N-(5-(3-(trifluoromethyl)phenyl)thiazol-2-yl)-benzamide

: 1354721-62-2
N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1877-71-0
benzene 1,3-dicarboxylic acid monomethyl ester

: 1354721-62-2
N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 40 h / 40 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 25 °C

3.2: pH 2 - 3

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 50 °C

5.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1354721-62-2
N-methyl-N-(2-morpholinoethyl)-N'-(4-(piperidin-1-yl)-2-((4-(3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)phenyl)isophthalamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydroxide; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 25 °C

4.2: pH 2 - 3

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 50 °C

6.1: pyridine / dichloromethane / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; lithium hydroxide monohydrate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;