isopropylidene phenyl(γ-oxobutyl)malonate

Base Information

• Chemical Name: isopropylidene phenyl(γ-oxobutyl)malonate
• CAS No.: 82431-01-4
• Molecular Formula: C₁₆H₁₈O₅
• Molecular Weight: 290.316
• Mol file: 82431-01-4.mol

Synonyms:isopropylidene phenyl(γ-oxobutyl)malonate

Chemical Property of isopropylidene phenyl(γ-oxobutyl)malonate

Chemical Property:

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Technology Process of isopropylidene phenyl(γ-oxobutyl)malonate

There total 1 articles about isopropylidene phenyl(γ-oxobutyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione (15231-78-4) + 1-Dimethylamino-3-butanon (2543-57-9) → isopropylidene phenyl(γ-oxobutyl)malonate (82431-01-4)

Guidance literature:

With acetic anhydride; In 1,2-dimethoxyethane; at 55 ℃;

DOI:10.1021/jo00140a038

Reference yield: 95.0%

isopropylidene phenyl(γ-oxobutyl)malonate (82431-01-4) → α-phenyl-δ-oxocaproic acid (5662-73-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1021/jo00140a038

upstream raw materials:

2.2-dimethyl-5-phenyl-1,3-dioxane-4,6-dione

1-Dimethylamino-3-butanon

Downstream raw materials:

α-phenyl-δ-oxocaproic acid