2543-57-9Relevant articles and documents
Chemical and biological profile of racemic and optically active dialkylaminoalkylnaphthalenes with analgesic activity
Azzolina, Ornella,Collina, Simona,Brusotti, Gloria,Rossi, Daniela,Callegari, Athos,Linati, Laura,Barbieri, Annalisa,Ghislandi, Victor
, p. 1073 - 1081 (2002)
The racemic mixtures and the enantiomers of dialkylaminoalkylnaphthalenes are described here as novel analgesic agents with potencies similar, or superior to that of morphine. The synthesis and isolation of the pure enantiomers and a study of the absolute
Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines
Rossi, Daniela,Rui, Marta,Di Giacomo, Marcello,Schepmann, Dirk,Wünsch, Bernhard,Monteleone, Stefania,Liedl, Klaus R.,Collina, Simona
, p. 11 - 19 (2016/12/22)
Sigma Receptor (SR) modulators are involved in different signal transduction pathways, representing important pharmacological/therapeutic tools in several pathological conditions, such as neurodegenerative diseases and cancers. To this purpose, numerous c
Identification of a potent and selective ρ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells
Rossi, Daniela,Pedrali, Alice,Urbano, Mariangela,Gaggeri, Raffaella,Serra, Massimo,Fernández, Leyden,Fernández, Michael,Caballero, Julio,Ronsisvalle, Simone,Prezzavento, Orazio,Schepmann, Dirk,Wuensch, Bernhard,Peviani, Marco,Curti, Daniela,Azzolina, Ornella,Collina, Simona
scheme or table, p. 6210 - 6224 (2011/12/02)
Herein we report the synthesis, drug-likeness evaluation, and in vitro studies of new sigma (ρ) ligands based on arylalkenylaminic scaffold. For the most active olefin the corresponding arylalkylamine was studied. Novel arylalkenylamines generally possess