Technology Process of 24-(phenylsulfinyl)-22-(phenylsulfonyl)spiro<4,24-cholestadiene-3,2'-(1',3'-dithiacyclohexane)>
There total 10 articles about 24-(phenylsulfinyl)-22-(phenylsulfonyl)spiro<4,24-cholestadiene-3,2'-(1',3'-dithiacyclohexane)> which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / phosphorus pentoxide / CH2Cl2 / 18 h
2: 1.) NBS, 2.) lithium bromide / 1.) acetonitrile, 5 min, 2.) 2.5 h
3: 66.5 percent / MCPBA / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) -78 deg C -> room temperature, 1.5 h
4: 1.) n-butyllithium, TMEDA, 2.) hexamethylphosphoramide / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 15 min; -78 deg C -> -45 deg C , 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; phosphorus pentaoxide; N-Bromosuccinimide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 3-chloro-benzenecarboperoxoic acid; lithium bromide;
In
dichloromethane;
DOI:10.1021/ja00353a037
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NBS, 2.) lithium bromide / 1.) acetonitrile, 5 min, 2.) 2.5 h
2: 66.5 percent / MCPBA / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) -78 deg C -> room temperature, 1.5 h
3: 1.) n-butyllithium, TMEDA, 2.) hexamethylphosphoramide / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 15 min; -78 deg C -> -45 deg C , 1 h
With
N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; 3-chloro-benzenecarboperoxoic acid; lithium bromide;
In
dichloromethane;
DOI:10.1021/ja00353a037
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / sodium borohydride / ethanol / 0.25 h / 0 °C
2: 61 percent / boron trifluoride etherate / CH2Cl2 / 12 h
3: 87 percent / pyridine / 0 deg C -> room temperature, 3 h
4: potassium iodide / dimethylformamide / 6 h / 75 °C
5: dimethylformamide / 12 h / 74 °C
6: 1.) n-butyllithium, TMEDA, 2.) hexamethylphosphoramide / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 15 min; -78 deg C -> -45 deg C , 1 h
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; boron trifluoride diethyl etherate; potassium iodide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00353a037
