Technology Process of (2S,3S)-2,3-epoxy-2-(benzyloxymethyl)pentanal
There total 5 articles about (2S,3S)-2,3-epoxy-2-(benzyloxymethyl)pentanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2-Iodobenzoic acid;
In
ethyl acetate;
at 0 - 80 ℃;
for 5h;
DOI:10.1002/chem.201304776
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisobutylaluminium hydride / diethyl ether; n-heptane / 2 h / -78 °C
2: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane; decane / 1 h / -20 °C / Molecular sieve
3: 2-Iodobenzoic acid / ethyl acetate / 5 h / 0 - 80 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; 2-Iodobenzoic acid; diisobutylaluminium hydride;
In
diethyl ether; decane; n-heptane; dichloromethane; ethyl acetate;
2: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/chem.201304776
- Guidance literature:
-
Multi-step reaction with 2 steps
1: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane; decane / 1 h / -20 °C / Molecular sieve
2: 2-Iodobenzoic acid / ethyl acetate / 5 h / 0 - 80 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; 2-Iodobenzoic acid;
In
decane; dichloromethane; ethyl acetate;
1: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/chem.201304776
