Technology Process of (4R,5S,6S)-5-(benzyloxymethyl)-5,6-epoxyoct-1-en-4-ol
There total 6 articles about (4R,5S,6S)-5-(benzyloxymethyl)-5,6-epoxyoct-1-en-4-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,3S)-2,3-epoxy-2-(benzyloxymethyl)pentanal;
With
magnesium; ethylene dibromide;
In
diethyl ether; dichloromethane;
at -78 - 20 ℃;
for 0.166667h;
Reflux;
allyltributylstanane;
In
dichloromethane;
at -78 ℃;
for 1.5h;
DOI:10.1002/chem.201304776
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2-Iodobenzoic acid / ethyl acetate / 5 h / 0 - 80 °C
2.1: ethylene dibromide; magnesium / diethyl ether; dichloromethane / 0.17 h / -78 - 20 °C / Reflux
2.2: 1.5 h / -78 °C
With
2-Iodobenzoic acid; magnesium; ethylene dibromide;
In
diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1002/chem.201304776
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trifluorormethanesulfonic acid / cyclohexane / 20 °C
2.1: diisobutylaluminium hydride / diethyl ether; n-heptane / 2 h / -78 °C
3.1: titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate / dichloromethane; decane / 1 h / -20 °C / Molecular sieve
4.1: 2-Iodobenzoic acid / ethyl acetate / 5 h / 0 - 80 °C
5.1: ethylene dibromide; magnesium / diethyl ether; dichloromethane / 0.17 h / -78 - 20 °C / Reflux
5.2: 1.5 h / -78 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; trifluorormethanesulfonic acid; 2-Iodobenzoic acid; diisobutylaluminium hydride; magnesium; ethylene dibromide;
In
diethyl ether; decane; n-heptane; dichloromethane; cyclohexane; ethyl acetate;
3.1: |Sharpless Asymmetric Epoxidation;
DOI:10.1002/chem.201304776
