2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine

Base Information

• Chemical Name: 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine
• CAS No.: 1380672-04-7
• Molecular Formula: C₂₅H₂₀ClN₇O₃
• Molecular Weight: 501.932
• Mol file: 1380672-04-7.mol

Synonyms:2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine

Chemical Property of 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine

There total 5 articles about 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.5%

(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid (1380672-63-8) + N-amino-N'-(2-chlorophenyl)-5-ethoxy-pyridine-2-carboxamidine (1380672-70-7) → 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine (1380672-04-7)

Guidance literature:

(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid; With trichlorophosphate; In toluene; for 2h; Reflux;

N-amino-N'-(2-chlorophenyl)-5-ethoxy-pyridine-2-carboxamidine; In dichloromethane; at 20 ℃; for 5h; Reflux;

Reference yield:

5-bromoisonicotinic acid (30766-11-1) → 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine (1380672-04-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 18 h / 20 °C

2.1: sodium / ethanol / 3 h / Reflux

3.1: trimethylaluminum / toluene / 0.5 h / 20 °C

3.2: 15 h / 20 °C

4.1: phosphorus pentachloride / benzene / 2 h / Reflux

4.2: 0.5 h / Reflux

5.1: trichlorophosphate / toluene / 2 h / Reflux

5.2: 5 h / 20 °C / Reflux

With thionyl chloride; phosphorus pentachloride; trimethylaluminum; sodium; trichlorophosphate; In ethanol; toluene; benzene;

Reference yield:

2-methoxy-isonicotinic acid hydrazide (19353-97-0) → 2-(4-(2-chlorophenyl)-5-((E)-2-(5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazol-2-yl)vinyl)-4H-1,2,4-triazol-3-yl)-5-ethoxypyridine (1380672-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: trichlorophosphate / toluene / 2 h / Reflux

2.2: 5 h / 20 °C / Reflux

With trichlorophosphate; In tetrahydrofuran; toluene;

upstream raw materials:

5-bromoisonicotinic acid

2-methoxy-isonicotinic acid hydrazide

(Z)-4-(2-methoxypyridine-4-carboamido)-4-oxobut-2-enoic acid

N-amino-N'-(2-chlorophenyl)-5-ethoxy-pyridine-2-carboxamidine