N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

Base Information

Chemical Name:N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine
CAS No.:1373431-59-4
Molecular Formula:C₃₀H₃₇N₄O₇P
Molecular Weight:596.62
Hs Code.:

Synonyms:N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

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Chemical Property of N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

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Technology Process of N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

There total 4 articles about N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1373431-58-3
5-[bis(4-methoxyphenyl)phosphanyl]pyrrole-2-carboxyl-1-carboxylic acid 1-tert-butyl ester

: 219511-71-4
tert-butyl N-(diaminomethylidene)carbamate

: 1373431-59-4
N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 17h; Inert atmosphere;
DOI:10.1002/anie.201108946

Reference yield:

: 1373431-57-2
N-(tert-butoxycarbonyl)-2-bis(4-methoxyphenyl)phosphanylpyrrole

: 1373431-59-4
N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethyl phosphite; n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: 2 h / -40 °C / Inert atmosphere

2.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; trimethyl phosphite; n-butyllithium; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201108946

Reference yield:

: 5176-27-2
N-tert-butyloxycarbonyl-pyrrole

: 1373431-59-4
N''-tert-butoxycarbonyl-N-(1-tert-butoxycarbonyl-5-bis(4-methoxyphenyl)phosphanylpyrrol-2-carbonyl)guanidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethyl phosphite; n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: trimethyl phosphite; n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

2.2: 2 h / -40 °C / Inert atmosphere

3.1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; trimethyl phosphite; n-butyllithium; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201108946