N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

Base Information

Chemical Name:N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide
CAS No.:1310570-76-3
Molecular Formula:C₁₇H₁₄ClN₃O₄S
Molecular Weight:391.835
Hs Code.:

Synonyms:N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

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Chemical Property of N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

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Technology Process of N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

There total 4 articles about N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2142-68-9
1-(2-chlorophenyl)ethanone

: 184971-42-4
4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

: 1310570-76-3
N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

Guidance literature:: With phosphoric acid; In methanol; for 0.0833333h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.03.020

Reference yield:

: 6639-62-9
methyl 3-oxo-2,3-dihydrobenzo[d][1,2]thiazol-2-acetate 1,1-dioxide

: 1310570-76-3
N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 0.5 h / 55 °C / Inert atmosphere

1.2: pH Ca_. 3 / Cooling with ice

2.1: hydrazine hydrate / methanol / 0.58 h / Reflux

2.2: Cooling

3.1: phosphoric acid / methanol / 0.08 h / Microwave irradiation

With phosphoric acid; sodium methylate; hydrazine hydrate; In methanol; 1.1: Gabriel-Colman type ring expansion;
DOI:10.1016/j.ejmech.2011.03.020

Reference yield:

: 128-44-9
saccharin sodium salt

: 1310570-76-3
N'-[(1E)-1-(2-chlorophenyl)ethylidene]-4-hydroxy-2H-1,2-benzothiazine-3-carbohydrazide 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 0.05 h / Microwave irradiation

2.1: sodium methylate / methanol / 0.5 h / 55 °C / Inert atmosphere

2.2: pH Ca_. 3 / Cooling with ice

3.1: hydrazine hydrate / methanol / 0.58 h / Reflux

3.2: Cooling

4.1: phosphoric acid / methanol / 0.08 h / Microwave irradiation

With phosphoric acid; sodium methylate; hydrazine hydrate; In methanol; N,N-dimethyl-formamide; 2.1: Gabriel-Colman type ring expansion;
DOI:10.1016/j.ejmech.2011.03.020